2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (284):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-169087
    MJBIA9836
    MJBIA9836yes PROTACLigands for target proteins can be used to synthesize PROTACMolecules, such as MS41 (HY-169086).
    MJBIA9836
  • HY-160094
    BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol) 2126749-81-1
    BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol (compound 71) is a Ligands for Target Protein for PROTAC that contains a sulfonamide linker to increase the solubility of the linker-conjugate. BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol can be used to synthesize PROTACs with antitumor activity.
    BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol)
  • HY-169180
    AK-068-OH 2982851-61-4
    AK-068-OH (Compound 49) is an active control of ligand for target protein for PROTAC (HY-169179).
    AK-068-OH
  • HY-169094
    PFI-6-COOH 2768514-05-0
    PFI-6-COOH (Compound 18) is an eleven-nineteen leukemia (ENL) ligand, and can be used for synthesis of MS41 (HY-169093), an ENL PROTAC degrader.
    PFI-6-COOH
  • HY-46340
    AZD9496 deacrylic acid phenol 2173404-70-9
    AZD9496 deacrylic acid phenol is a fragment of target protein ligand of PROTAC ER Degrader-4 (HY-135309).
    AZD9496 deacrylic acid phenol
  • HY-168248
    BRM/BRG1 ligand 2 2933125-88-1
    BRM/BRG1 ligand 2 is the ligand for target protein, which can be used for synthesis of PROTAC BRM/BRG1 degrader-2 (HY-168247).
    BRM/BRG1 ligand 2
  • HY-141486A
    PROTAC PARP/EGFR ligand 1 2661609-57-8
    PROTAC PARP/EGFR ligand 1 is an active compound that can be used for the synthesis of dual PARP EGFR degraders by proteolytic targeting chimera (PROTAC) technology.
    PROTAC PARP/EGFR ligand 1
  • HY-158433
    KDM5B ligand 2
    KDM5B ligand 2 is the ligand for target protein KDM5B. KDM5B ligand 2 is utilized for synthesis of KDM5B PROTAC GT-653 (HY-158432).
    KDM5B ligand 2
  • HY-159009
    MS7 1593654-46-6
    MS7 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). NAMPT is overexpressed in many cancer cells to meet the continuous replenishment of NAD+ required for rapid proliferation. MS7, as a NAMPT target protein ligand, can be used to synthesize PROTAC A7, which is an effective NAMPT degrader. MS7 can be used in cancer research.
    MS7
  • HY-170988
    FKBP12 ligand-1 178446-02-1
    FKBP12 ligand-1 is a targeting protein ligand of MC-25B (HY-170983), which is a specific FKBP12 PROTAC.
    FKBP12 ligand-1
  • HY-111843
    Ch55-O-C3-NH2 144298-98-6
    Ch55-O-C3-NH2 (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-NH2 (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.
    Ch55-O-C3-NH2
  • HY-170997
    CypA ligand-1
    CypA ligand-1 is the ligand for CypA that can be used as target protein ligand for synthesis of PROTAC degrader PROTAC CG167 (HY-173009).
    CypA ligand-1
  • HY-169379
    CSI118 TFA 3063898-01-8
    CSI118 TFA (Compound 1) is a Ligand for Target Protein for PROTAC. CSI118 TFA can be used to synthesize CSI86 (HY-169378).
    CSI118 TFA
  • HY-143270
    PROTAC BRD9-binding moiety 5 893633-37-9
    PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC50 value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells.
    PROTAC BRD9-binding moiety 5
  • HY-19991A
    (Rac)-BMS-1 1675201-97-4
    (Rac)-BMS-1 is a racemate of BMS-1 (HY-19991A). (Rac)-BMS-1 can be used as a target protein ligand to synthesize D5B PROTAC (HY-169392).
    (Rac)-BMS-1
  • HY-111845
    Estrone-N-O-C1-amido 138219-84-8
    Estrone-N-O-C1-amido (ERα ligand 1) is an Estrone-based estrogen ligand, which targets estrogen receptor α (ERα). Estrone-N-O-C1-amido (ERα ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.
    Estrone-N-O-C1-amido
  • HY-168017
    NSC682769 205048-79-9
    NSC682769 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). NSC682769 can be used for synthesis PROTAC YAP degrader-1 (HY-168016).
    NSC682769
  • HY-169049
    Smurf1 ligand 1
    Smurf1 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Smurf1 ligand 1 can be used for synthesis SMART1 (HY-W998345).
    Smurf1 ligand 1
  • HY-173012
    CypA ligand-2
    CypA ligand-2 is the target protein ligand of PROTAC RJS308 (HY-173011). RJS308 is a PROTAC targeting CypA and exhibits antiviral activity.
    CypA ligand-2
  • HY-170452
    MDM2 ligand 4
    MDM2 ligand 4 is the ligand for MDM2 that can be used for synthesis of PROTAC degrader KT-253 (HY-170451).
    MDM2 ligand 4